Preventive Effects of Saldi tierra Containing Various Trace Elements on Bone Loss in Rats with Diabetes or Adjuvant Arthritis
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概要
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The preventive effect of Saldi tierra containing various trace elements on bone loss which is induced in rats with diabetes or adjuvant arthritis were investigated. Rats received a single subcutaneous administration of streptozotocin (STZ) (6.0mg/100g body weight), and the animals were orally administered a solution of Saldi tierra (25 or 50mg/100g) once daily for 14 days. STZ-administered rats caused a significant increase in serum glucose, triglyceride, or calcium levels and a significant decrease in body weight or serum inorganic phosphorus levels. These alterations were significantly restored after the oral administration of Saldi tierra. The femoral-diaphyseal and -metaphyseal calcium contents were significantly decreased in STZ-diabetic rats. This decrease was significantly inhibited after the administration of Saldi tierra (25 or 50mg/100g). The decreases in diaphyseal and metaphyseal alkaline phosphatase activity and metaphyseal DNA content were significantly prevented after the administration of Saldi tierra (50mg/100g). Meanwhile, rats received an injection of 1 % Mycobacterium butyricum suspension into the subplantar surface of the right hind paw, and the animals were orally administered Saldi tierra (50mg/100g) once daily for 18 days. Calcium content, alkaline phosphatase activity, and DNA content in the femoral-metaphyseal tissues were significantly decreased in rats with adjuvant arthritis. These decreases were significantly inhibited after the administration of Saldi tierra (50mg/100g). This study demonstrates that the intake of Saldi tierra has preventive effects against bone loss in rats with diabetes or adjuvant arthritis in vivo.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Uchiyama Satoshi
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi M
Univ. Shizuoka Sizuoka Jpn
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Kouno Shigeo
Research & Development, Tokai Ever Clean Ltd.
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Uchiyama Satoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Kouno Shigeo
Research & Development Tokai Ever Clean Ltd.
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Uchiyama Satoshi
Laboratory Of Biology Faculty Of Education And Human Sciences Niigata University
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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