Inhibitory Effect of Calcium-binding Protein Regucalcin on Protein Kinase C Activity in Rat Renal Cortex Cytosol
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概要
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The effect of regucalcin, a calcium-binding protein, on Ca^<2+> -and phospholipid-dependent protein kinase (protein kinase C) activity in the cytosol of rat kidney cortex was investigated. With increasing concentratoins of Ca^<2+>, phosphatidylserine or dioctanoylglycerol in the reaction mixture, regucalcin (10^<-8>M) caused a remarakble inhibition of protein kinase C activity. Regucalcin did not have a significant effect on protein kinase C activity in the presence of phosphatidylserine or dioctanoylglycerol without Ca^<2+> addition. Moreover, regucalcin significantly inhibited phorbol 12-myristate 13-acetate (PMA)-increased protein kinase C activity. Meanwhile, staurosporine (10^<-9>M) caused a signidficant inhibition of protein kinase C activity. This inhibition was further enhanced by regucalcin addition. Regucalcin itself did not have protein kinase activity in either the presence or the absence ot both Ca^<2+> and phospholipids. These results clearly indicate that regucalcin has an inhibitory effect on protein kinase C activity in the cytosol of rat kidney cortex. This inhibitory effect may be partly due to the regucalcin-induced Ca^<2+> binding.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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KUROTA Hideyuki
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka
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Kurota Hideyuki
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences University Of Shizuoka
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