Preventive Effect of Dietary Fermented Soybean on Bone Loss in Ovariectomized Rats : Enhancement with Isoflavone and Zinc Supplementation
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概要
- 論文の詳細を見る
The effect of experimental diets with fermented soybean (natto) containing isoflavone and zinc on ovariectomy (OVX)-induced bone loss was investigated. Sham-operated rats or OVX rats were given experimental diets containing soybean protein for 3 months, and other OVX rats were fed dietary natto, with or without calcium, calcium plus zinc, calcium plus isoflavone or calcium plus zinc and isoflavone for 3 months. Experimental diets contained 2.1 to 9.7mg zinc per 100g and 44.6 to 92.4mg isoflavone (including genistin, genistein, daidzin, and daidzein) per 100g. OVX caused a significant reduction in the dry weight and mineral density of the femur. Also, the calcium content, zinc content and alkaline phosphatase activity in femoral-diaphyseal and metaphyseal tissues was significantly reduced by OVX. These reductions were largely prevented by feeding natto diets. This prevention was significantly enhanced in OVX rats fed natto diets supplemented with isoflavone and zinc. This study demonstrates that the prolonged intake of dietary natto supplemented with isoflavone and zinc has a preventive effect on OVX-induced bone loss, suggesting that it may have a role in the prevention of osteoporosis.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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YAMAGUCHI Masayoshi
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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MA Zhong
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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IGARASHI Aki
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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Ma Z
Univ. Shizuoka Shizuoka Jpn
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Ma Zhong
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi A
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi Aki
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Shimanuki Shigefumi
Foods Science Laboratory, Taishi Food Inc.
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Kawasaki Yoshiyuki
Foods Science Laboratory, Taishi Food Inc.
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Shimanuki Shigefumi
Foods Science Laboratory Taishi Food Inc.
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Kawasaki Yoshiyuki
Foods Science Laboratory Taishi Food Inc.
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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