Oral Administration of β-Cryptoxanthin Prevents Bone Loss in Streptozotocin-Diabetic Rats in Vivo(Pharmacology)
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概要
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The effects of β-cryptoxanthin, a carotenoid, on bone components in the femoral-diaphyseal and -metaphyseal tissues of streptozotocin (STZ)-diabetic rats was investigated. Rats received a single subcutaneous administration of STZ (6.0mg/100g body weight), and then the animal were orally administered β-cryptoxanthin (5 or 10μg/100g body weight) once daily for 7 or 14d. The administration of STZ caused a significant decrease in body weight and a significant increase in serum glucose, triglyceride, and calcium levels, indicating a diabetic state. These alterations were significantly prevented by the administration of β-cryptoxanthin (5 or 10μg/100g) for 14d. The administration of β-cryptoxanthin (5 or 10μg/100g) to normal rats for 14d did not have a significant effect on body weight or on serum glucose, triglyceride, and calcium levels. Calcium content, alkaline phosphatase activity, and DNA content in the femoral-diaphyseal and -metaphyseal tissues were significantly decreased in STZ-diabetic rats. These decreases were significantly prevented by the administration of β-cryptoxanthin (5 or 10μg/100g) for 14d. The administration of β-cryptoxanthin to normal rats for 14d caused a significant increase in calcium content, alkaline phosphatase activity, and DNA content in the femoral-diaphyseal and -metaphyseal tissues. This study demonstrates that the intake of β-cryptoxanthin has a preventive effect on bone loss in STZ-diabetic rats.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Uchiyama Satoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Uchiyama Satoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Uchiyama Satoshi
Laboratory Of Biology Faculty Of Education And Human Sciences Niigata University
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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