抗炎症剤に関する研究(第2報)黄連の抗炎症活性成分

概要

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Berberine-containing plants are fairly widely distributed in the plant kingdom. From old times, they have been used for Chinese medicine or folk medicine. The Coptidis Rhizoma is especially prescribed in Chinese medicine for the purpose of antiphlogistic, analgesic, sedative, antidotal, hemostatic, and stomachic effects. Among efficacies of the medicine, the antiphlogistic effect has not been evidenced pharmacologically. We have investigated the anti-inflammatory active constituents in the rhizomes of Coptis japonica MAKINO by tracing the activity by means of the fertile egg method. Consequently, the active principles have been proved to be berberine, coptisine, jateorrhizine, and palmatine. Activity of berberine was also confirmed by means of cotton-pellet method, croton oil-granuloma pouch method, and punch method.
公益社団法人日本薬学会の論文
1981-10-25