Characterization of Monoclonal Antibodies against (1R, 2R)-Cyclohexanediamine Platinum(II)-DNA Adduct
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概要
- 論文の詳細を見る
Two monoclonal antibodies raised against Pt(II)(1R, 2R-cyclohexanediamine)-DNA were prepared, and the specificity of the monoclonal antibodies against Pt(II)(cyclohexanediamine)-DNA derivatives was determined by competitive enzyme-linked immunosorbent assay. The binding affinity of the monoclonal antibodies is apparently influenced by the cyclohexanediamine moiety of Pt(II)(cyclohexanediamine)-DNA adducts, but the monoclonal antibodies can not bind to the low molecular analogue, Pt(II)(1R, 2R-cyclohexanediamine)-d(GpG), which is the intrastrand binding model compound of Pt(II)(1R, 2R-cyclohexanediamine)-DNA. Therefore, the monoclonal antibodies recognize the macromolecular parts, including DNA duplex, in addition to the cyclohexane moieties of the platinum complexes on Pt(II)(cyclohexanediamine)-DNA adducts.
- 公益社団法人日本薬学会の論文
- 1996-09-15
著者
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INOUE Kaori
Department of Diagnostic Pathology, Kochi Red Cross Hospital
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YAMAGUCHI Yube
Research and Education Center for Genetic Information, Nara Institute of Science and Technology
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Inagaki K
Nagoya City Univ. Nagoya Jpn
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Yamaguchi Y
Department Of Bioresources Science Graduate School Of Science And Technology Chiba University
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HIROMI Keitaro
Department of Food Science and Technology, Faculty of Engineering, Fukuyama University
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IWAMOTO Hiroyuki
Department of Food Science and Technology, Faculty of Engineering, Fukuyama University
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HIROSE Junzo
Department of Food Science and Technology, Faculty of Engineering, Fukuyama University
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Yamaguchi Yoshitaka
Department Of Biotechnology Faculty Of Engineering Fukuyama University
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MORIMOTO Eiichiro
Department of Food Science and Technology, Faculty of Engineering, Fukuyama University
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YAMAGUTI Yasunori
Department of Biotechnology, Faculty of Engineering, Fukuyama University
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KITASE Masaru
Nagoya City Environmental Science Research Institute
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INAGAKI Kenji
Seirei Christian Colledge of Nursing
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Inoue Kaori
Department Of Cardiology Nagoya Memorial Hospital
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Morimoto Eiichiro
Department Of Food Science And Technology Faculty Of Engineering Fukuyama University
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Inoue Kaori
Department Of Food Science And Technology Faculty Of Engineering Fukuyama University
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Yamaguchi Y
Research And Education Center For Genetic Information Nara Institute Of Science And Technology
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Hirose J
Kyoto Women's Univ. Kyoto Jpn
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Hirose Junzo
Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
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Hirose Junzo
Department Of Applied Biological Science Faculty Of Life Science And Biotechnology Fukuyama Universi
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Iwamoto Hisao
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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Hiromi Keitaro
Department Of Food Science And Technology Faculty Of Engineering Fukuyama University
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Hiromi Keitaro
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Hirayama K
Univ. Tokyo Tokyo Jpn
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Iwamoto H
Laboratory Of Food And Biomolecular Science Graduate School Of Agricultural Science Tohoku Universit
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Iwamoto Hiroyuki
Department Of Applied Biological Science Faculty Of Life Science And Biotechnology Fukuyama Universi
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HIROMI Keitaro
Department of Food Science & Technology, Faculty of Agriculture, Kyoto University
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