Effects of Two Synthetic Serum Thymic Factor Analogues and Four Thymic Factor Fragments on the Low E-Rosette Forming Cells in Patients with Chronic Renal Failure
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概要
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Two new analogues of serum thymic factor (STF), [Dab^3]- and [Asn^5,Gln^9]-STF and four thymic factor fragments, H-Lys-Ser-Gln-OH, H-Lys-Ser-Gln-Gly-OH, H-Lys-Ser-Gln-Gly-OH and H-Lys-Ser-Gln-Gly-Gly-Ser-OH, were synthesized by the solution method, and were tested to determine their effects on the low E-rosette forming cells in patients with chronic renal failure. The analogue [Dab^3]-STF and three fragments, H-Lys-Ser-Gln-Gly-OH, H-Lys-Ser-Gln-Gly-Gly-OH and H-Lys-Ser-Gln-Gly-Gly-Ser-OH, increased E-rosette forming capacity when incubated in vitro with patient's blood, but [Asn^5,Gln^9]-STF and the tripeptide, H-Lys-Ser-Gln-OH, had no effect.
- 公益社団法人日本薬学会の論文
- 1982-12-25
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