Synthesis of Deacetyl-thymosin β_<10> and Examination of Its Immunological Effect on T-Cell Subpopulations of a Uremic Patient with Tuberculosis
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Deacetyl-thymosin β_<10> was synthesized by a conventional solution method, by assembling seven peptide fragments followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The synthetic deacetyl-thymosin β_<10> increased the entire peripheral T-cell population and a helper T-cell subset when incubated in vitro with blood obtained from a uremic patient with tuberculosis, but a suppressor/cytotoxic T-cell subset was unaffected under these conditions.
- 公益社団法人日本薬学会の論文
- 1986-11-25
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