Synthesis of the Eicosapeptide corresponding to the N-Terminal Amino Acid Sequence of the Major Component of Human Lymphoblastoid Interferon
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概要
- 論文の詳細を見る
An eicosapeptide, H-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Asn-Arg-Arg-Ala-Leu-Ile-Leu-Leu-Ala-Gln-OH, corresponding to the N-terminal amino acid sequence of the major component of human lymphoblastoid interferon was synthesized by a conventional method. The final deprotected peptide was purified by gel filtration on Sephadex G-25 and then by partition chromatography on Sephadex G-25. The eicosapeptide at a dose of 100 μg/ml inhibited the incorporation of ^3H-thymidine into DNA of PHA-induced lymphocytes by about 15%.
- 公益社団法人日本薬学会の論文
- 1981-05-23
著者
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関野 宏
Kidney Research Laboratory Kojinkai
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安孫子 敬
Kidney Research Laboratory Kojinkai
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小野寺 育子
Kidney Center, Sendai Insurance Hospital
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小野寺 育子
Kidney Center Sendai Insurance Hospital
関連論文
- Study on Influence of Synthetic Glucagon Fragment on Lymphocyte Transformation. I
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- Synthesis of a Thymosin β_4-Like Peptide, Deacetyl-thymosin β^_4,and Its Restorative Effect on Depressed Lymphocyte Blastogenic Response to Phytohemagglutinin (PHA) in Uremic Patients
- Synthesis of [Glu^]Human Splenin (hSP) and Examination of Its Immunological Effect on the Reduced B-Lymphocytes of Uremic Patients
- Synthesis of Human Thymopoietin (hTP) and Examination of Its Immunological Effect on the Impaired Blastogenic Response of T-Lymphocytes of Uremic Patients
- Synthesis of Deacetyl-thymosin β_7 and Examination of Its Immunological Effect on the Blastogenic Response of T-Lymphocytes of a Uremic Patient with Cell-Mediated Immunodeficiency
- Synthesis of the Revised Amino Acid Sequence of Thymopoietin II and Examination of Its Immunological Effect on the Impaired T-Lymphocyte Transformation of a Uremic Patient with Pneumonia(Biological)
- Synthesis of Deacetyl-thymosin β_ and Examination of Its Immunological Effect on T-Cell Subpopulations of a Uremic Patient with Tuberculosis
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- The Effect of Ubiquitin Hexadecapeptide Fragment on E-Rosette Forming Cells of a Uremic Patient
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- Synthesis of the Eicosapeptide corresponding to the N-Terminal Amino Acid Sequence of the Major Component of Human Lymphoblastoid Interferon
- Synthesis and Immunological Effects of Thymosin α_1 and Its Fragments on Inhibitory Factor in Minimal Change Nephrotic Syndrome
- The Effect of Thymopoietin II Fragments and Their Analogs on E-Rosette Forming Cells in the Uremic State
- Characterization of an Acidic Tripeptide in Neurotoxic Dialysate
- The Effect of a Synthetic Thymosin α_1 Fragment on the Inhibition of E-rosette Formation by the Serum of a Patient with Nephrotic Syndrome
- The Effects of Synthetic Glucagon Fragments on Glucose-6-phosphate Dehydrogenase. II
- Synthesis and Effects of Two Peptide Fragments of Thymopoietin II on E-Rosette Forming Cells in the Uremic State
- Synthesis of Bradykinyl-peptide and Peptidyl-bradykinin
- Syntheses of [Phe (4NO_2)^5,Tyr (Me)^8]-and [Tyr (Me)^5,Phe (4NO_2)^8]-Bradykinin