Synthesis of a Thymosin β_4-Like Peptide, Thymosin β^<Met>_9,and Its Effect on Low E-Rosette-Forming Lymphocytes of Lupus Nephritis Patients

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概要

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• A thymosin β_4-like peptide, thymosin β^<Met>_9 isolated from pork spleen, was synthesized using a conventional solution method. The deprotection of the protected thymosin β^<Met>_9 was achieved by treatment with Zn-90% AcOH to remove C-terminal ρ-nitrobenzyl ester and then with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1 : 1) in trifluoroacetic acid in the presence of dimethylselenium. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain.The increase of the E-rosette-forming lymphocytes was obtained after incubation of peripheral blood from lupus nephritis patients with the synthetic thymosin β^<Met>_9. The synthetic thymosin β^<Met>_9 was approximately equal in potency to that of our synthetic calf thymosin β_9.

• 公益社団法人日本薬学会の論文
• 1990-08-25

著者

• 関野 宏

  Kidney Research Laboratory Kojinkai

• 安孫子 敬

  Kidney Research Laboratory Kojinkai

関連論文

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