Synthesis of Human Thymopoietin (hTP) and Examination of Its Immunological Effect on the Impaired Blastogenic Response of T-Lymphocytes of Uremic Patients
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概要
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The octatetracontapeptide corresponding to the entire amino acid seuence of human thymopoietin (hTP) was synthesized by assembling ten peptide fragments in solution followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1 : 1) in trifluoroacetic acid in the presence of dimethylselenide and m-cresol. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic peptide was found to have a restoring effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients.
- 公益社団法人日本薬学会の論文
- 1988-07-25
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