Synthesis and Immunological Effect of Deacetyl-thymosin α_<11> on Low E-Rosette-Forming Cells of a Rheumatoid Arthritis Patient
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概要
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Deacetyl-thymosin α_<11> was synthesized by successive azide condensations of seven peptide fragments, Boc-(1-3)-NHNH_2,Boc-(4-7)-NHNH_2,Boc-(8-11)-NHNH_2,Boc-(12-16)-NHNH_2,Boc-(17-22)-NHNH_2,Boc-(23-26)-NHNH_2 and Boc-(27-29)-NHNH_2,with H-(30-35)-OBzl, followed by deprotection with hydrogen fluoride in the presence of anisole and thioanisole. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a rheumatoid arthritis patient with the synthetic deacetyl-thymosin α_<11>. This synthetic deacetyl-thymosin α_<11> was approximately equal in potency to our synthetic deacetyl-thymosin α_1 in cases of rheumatoid arthritis.
- 公益社団法人日本薬学会の論文
- 1985-12-25
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