Immunological Effect of Two Synthetic Peptides Containing Alanine or D-Alanine Instead of Acetyl Group of Thymosin β_4 after Treatment of Human Serum
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概要
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Two analogs of thymosin β_4 the N-terminal acetyl groups of which were substituted by Ala or D-Ala, were synthesized by the solution method and studied for their immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum. One of the synthetic analogs, D-Ala-thymosin β_4 demonstrated a restorative effect on these patients when incubated in human serum, but the other analog, Ala-thymosin β_4,showed no restorative effect under the same conditions. These results seem to suggest that D-Ala-thymosin β_4 increases resistance to proteolytic degradation by exopeptidases more than Ala-thymosin β_4.
- 公益社団法人日本薬学会の論文
- 1990-09-25
著者
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