Deacetyl-thymosin β_4 : Synthesis and Effect on the Impaired Peripheral T-Cell Subsets in Patients with Chronic Renal Failure
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Deacetyl-thymosin β_4 was synthesized by successive azide condensations of five peptide fragments, Boc-(1-4)-NHNH_2,Boc-(5-12)-NHNH_2,Boc-(13-20)-NHNH_2,Boc-(21-27)-NHNH_2 and Boc-(28-33)-NHNH_2,with H-(34-43)-OBzl, followed by deprotection with hydrogen fluoride in the presence of anisole and thioanisole. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic deacetyl-thymosin β_4 increased almost the entire peripheral T-cell population and a helper T-cell subset when incubated in vitro with uremic patient's blood but a suppressor T-cell subset was unaffected under these conditions.
- 公益社団法人日本薬学会の論文
- 1984-11-25
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