Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Calf Thymosin β_8 and Its Effect on the Impaired T-Cell Subsets in Patients with Lupus Nephritis
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概要
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The nonatriacontapeptide corresponding to the entire amino acid sequence of calf thymosin β_8 was synthesized by the azide condensation of four fragments, (1-7), (8-20), (21-29) and (30-39), followed by deprotection with hydrogen fluoride in the presence of anisole-thioanisole. The synthetic nonatriacontapeptide increased almost the entire peripheral T-cell population and a suppressor T-cell subset when incubated in vitro with a lupus nephritis patient's peripheral blood, but the percentage of a helper T-cell subset did not change under these conditions.
- 公益社団法人日本薬学会の論文
- 1983-04-25
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