Effects of Synthetic Thymopoietin II Fragments on E-Rosette Forming Cells of a Rheumatoid Arthritis Patient

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概要

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• An octadecapeptide, H-Arg-Lys-Asp-Val-Tyr-Val-Gln-Leu-Tyr-Leu-Gln-Thr-Leu-Thr-Ala-Val-Lys-Arg-OH, corresponding to the C-terminal portion of thymopoietin II was synthesized using protecting groups removable by hydrogen fluoride treatment. The in vitro addition of the synthetic octadecapeptide was able to restore the low E-rosette forming capacity of cells in a rheumatoid arthritis patient to normal levels. The in vitro effects of pentapeptide (positions 32-36), nonapeptide (positions 33-41) and decapeptide (positions 32-41) fragments of thymopoietin on the low E-rosette forming capacity of cells of a rheumatoid arthritis patient were also compared with that of the synthetic octadecapeptide. The relative potency of the pentapeptide was 10.56 and that of the decapeptide was 25.43 based on the octadecapeptide (100.00) as a standard, but the nonapeptide was ineffective.

• 公益社団法人日本薬学会の論文
• 1981-08-25

著者

• 関野 宏

  Kidney Research Laboratory Kojinkai

• 安孫子 敬

  Kidney Research Laboratory Kojinkai

• 小野寺 育子

  Kidney Center, Sendai Insurance Hospital

• 小野寺 育子

  Kidney Center Sendai Insurance Hospital

関連論文

• Study on Influence of Synthetic Glucagon Fragment on Lymphocyte Transformation. I
• Synthesis of Rat Parathymosin α Fragment 1-28 and Examination of Its Inhibitory Activity towards the Restoring Activity of Thymosin α_1 on the Impaired T-Lymphocytes of Uremic Patients
• Synthesis of an Immunologically Active Fragment Analog of Prothymosin α with Enhanced Enzymatic Stability
• Immunological Effect of Two Synthetic Peptides Containing Alanine or D-Alanine Instead of Acetyl Group of Thymosin β_4 after Treatment of Human Serum
• Synthesis of a Thymosin β_4-Like Peptide, Thymosin β^_9,and Its Effect on Low E-Rosette-Forming Lymphocytes of Lupus Nephritis Patients
• Synthesis of Human Splenin (hSP) and Examination of Its Immunological Effects on the Impaired T-and B-Lymphocytes in Uremic Patients
• Syntheses and Effects of Human Splenin (hSP) Fragment 32-48 and an Analog on the Reduced B-Lymphocytes of Uremic Patients
• Synthesis of a Thymosin β_4-Like Peptide, Deacetyl-thymosin β^_4,and Its Restorative Effect on Depressed Lymphocyte Blastogenic Response to Phytohemagglutinin (PHA) in Uremic Patients
• Synthesis of [Glu^]Human Splenin (hSP) and Examination of Its Immunological Effect on the Reduced B-Lymphocytes of Uremic Patients
• Synthesis of Human Thymopoietin (hTP) and Examination of Its Immunological Effect on the Impaired Blastogenic Response of T-Lymphocytes of Uremic Patients
• Synthesis of Deacetyl-thymosin β_7 and Examination of Its Immunological Effect on the Blastogenic Response of T-Lymphocytes of a Uremic Patient with Cell-Mediated Immunodeficiency
• Synthesis of the Revised Amino Acid Sequence of Thymopoietin II and Examination of Its Immunological Effect on the Impaired T-Lymphocyte Transformation of a Uremic Patient with Pneumonia(Biological)
• Synthesis of Deacetyl-thymosin β_ and Examination of Its Immunological Effect on T-Cell Subpopulations of a Uremic Patient with Tuberculosis
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• Synthesis of the Eicosapeptide corresponding to the N-Terminal Amino Acid Sequence of the Major Component of Human Lymphoblastoid Interferon
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• The Effects of Synthetic Glucagon Fragments on Glucose-6-phosphate Dehydrogenase. II
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• Synthesis of Bradykinyl-peptide and Peptidyl-bradykinin
• Syntheses of [Phe (4NO_2)^5,Tyr (Me)^8]-and [Tyr (Me)^5,Phe (4NO_2)^8]-Bradykinin

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