Synthesis of [Glu^<34>]Human Splenin (hSP) and Examination of Its Immunological Effect on the Reduced B-Lymphocytes of Uremic Patients
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概要
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[Glu^<34>]human splenin (hSP) was synthesized in a conventional manner by assembling ten peptide fragments followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ration, 1 : 1) in trifluoroacetic acid in the presence of m-cresol and dimethylselenide. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. Incubation of peripheral lymphocytes isolated from uremic patients with the synthetic [Glu<34>]hSP showed an enhancing effect on the reduced B-lymphocytes, but synthetic human thymopoietin (hTP) had no effect under the same conditions.
- 公益社団法人日本薬学会の論文
- 1989-02-25
著者
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