Synthesis of an Immunologically Active Fragment Analog of Prothymosin α with Enhanced Enzymatic Stability

スポンサーリンク

概要

• 論文の詳細を見る

• A fragment analog, [D-Arg^<30>]prothymosin α fragment 1-30,containing D-arginine in place of arginine residue at position 30 was synthesized by the liquid phase procedure and studied for immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum. Deacetyl-thymosin α_1,a synthetic octaeicosapeptide corresponding to deacetyl-prothymosin α fragment 1-28,has restoration ability for the impaired blastogenic response of T-lymphocytes of uremic patients but is susceptible to proteolytic digestion. On the other hand, the fragment analog, [D-Arg^<30>]prothymosin α fragment 1-30 retained activity and was shown to exhibit a high degree of stability when incubated in human serum. These results indicate that N-terminal acetylation and the introduction of D-residue into the C-terminal residue of prothymosin α fragment 1-30 increase resistance to proteolytic degradation by exopeptidases.

• 公益社団法人日本薬学会の論文
• 1991-03-25

著者

• 関野 宏

  Kidney Research Laboratory Kojinkai

• 安孫子 敬

  Kidney Research Laboratory Kojinkai

関連論文

• Study on Influence of Synthetic Glucagon Fragment on Lymphocyte Transformation. I
• Synthesis of Rat Parathymosin α Fragment 1-28 and Examination of Its Inhibitory Activity towards the Restoring Activity of Thymosin α_1 on the Impaired T-Lymphocytes of Uremic Patients
• Synthesis of an Immunologically Active Fragment Analog of Prothymosin α with Enhanced Enzymatic Stability
• Immunological Effect of Two Synthetic Peptides Containing Alanine or D-Alanine Instead of Acetyl Group of Thymosin β_4 after Treatment of Human Serum
• Synthesis of a Thymosin β_4-Like Peptide, Thymosin β^_9,and Its Effect on Low E-Rosette-Forming Lymphocytes of Lupus Nephritis Patients
• Synthesis of Human Splenin (hSP) and Examination of Its Immunological Effects on the Impaired T-and B-Lymphocytes in Uremic Patients
• Syntheses and Effects of Human Splenin (hSP) Fragment 32-48 and an Analog on the Reduced B-Lymphocytes of Uremic Patients
• Synthesis of a Thymosin β_4-Like Peptide, Deacetyl-thymosin β^_4,and Its Restorative Effect on Depressed Lymphocyte Blastogenic Response to Phytohemagglutinin (PHA) in Uremic Patients
• Synthesis of [Glu^]Human Splenin (hSP) and Examination of Its Immunological Effect on the Reduced B-Lymphocytes of Uremic Patients
• Synthesis of Human Thymopoietin (hTP) and Examination of Its Immunological Effect on the Impaired Blastogenic Response of T-Lymphocytes of Uremic Patients
• Synthesis of Deacetyl-thymosin β_7 and Examination of Its Immunological Effect on the Blastogenic Response of T-Lymphocytes of a Uremic Patient with Cell-Mediated Immunodeficiency
• Synthesis of the Revised Amino Acid Sequence of Thymopoietin II and Examination of Its Immunological Effect on the Impaired T-Lymphocyte Transformation of a Uremic Patient with Pneumonia(Biological)
• Synthesis of Deacetyl-thymosin β_ and Examination of Its Immunological Effect on T-Cell Subpopulations of a Uremic Patient with Tuberculosis
• Synthesis of the Nonatetracontapeptide Corresponding to the Entire Amino Acid Sequence of Thymopoietin III and Its Effect on the Impaired T-Lymphocyte Transformation of a Patient with Common Variable Immunodeficiency
• Synthesis and Immunological Effect of Deacetyl-thymosin α_ on Low E-Rosette-Forming Cells of a Rheumatoid Arthritis Patient
• Synthesis of the Nonatetracontapeptide Corresponding to the Entire Amino Acid Sequence of Thymopoietin I and Its Effect on the Low E-Rosette-Forming Cells of a Uremic Patient
• Deacetyl-thymosin β_4 : Synthesis and Effect on the Impaired Peripheral T-Cell Subsets in Patients with Chronic Renal Failure
• Synthesis of Six Common Amino Acid Sequence Fragments of Thymosins β_4,β_8 and β_9 and Determination of Their Effects on the Low E-Rosette Forming Cells of Lupus Nephritis Patients
• Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Calf Thymosin β_8 and Its Effect on the Impaired T-Cell Subsets in Patients with Lupus Nephritis
• Effects of Two Synthetic Serum Thymic Factor Analogues and Four Thymic Factor Fragments on the Low E-Rosette Forming Cells in Patients with Chronic Renal Failure
• Synthesis of the Octadecapeptide corresponding to Positions 32 to 49 of the Revised Amino Acid Sequence of Thymopoietin II and Its Effect on Low E-Rosette Forming Cells of an Aged Patient with Chronic Renal Failure
• The Effect of Thymosin α_1 Fragments on T-Lymphocyte Transformation in the Uremic State
• Effect of Synthetic Serum Thymic Factor Fragments on the Inhibition of Sheep Erythrocyte Rosette Formation by Uremic Toxin
• The Effect of STF and Its Analogs on T Cells with Cellular Immunodeficiency
• Studies on Encephalitogenic Fragments of Myelin Protein. I. Synthesis of Tryptophan-containing Fragments
• Synthesis of Every Kinds of Peptide Fragments of Bradykinin
• A Study on Endocrine Disorder in Patients with Chronic Renal Failure. I. Synthesis and Biological Activity of Human Gastrin I
• Deacetyl-Thymosin α_1 : Synthesis and Immunological Effect on Lipoid Nephrosis Lymphocytes
• Effects of Synthetic Thymopoietin Fragments on Low E-Rosette Forming Cells in a Patient with Lupus Nephritis
• The Effect of Ubiquitin Hexadecapeptide Fragment on E-Rosette Forming Cells of a Uremic Patient
• Effects of Synthetic Thymopoietin II Fragments on E-Rosette Forming Cells of a Rheumatoid Arthritis Patient
• Synthesis of the Eicosapeptide corresponding to the N-Terminal Amino Acid Sequence of the Major Component of Human Lymphoblastoid Interferon
• Synthesis and Immunological Effects of Thymosin α_1 and Its Fragments on Inhibitory Factor in Minimal Change Nephrotic Syndrome
• The Effect of Thymopoietin II Fragments and Their Analogs on E-Rosette Forming Cells in the Uremic State
• Characterization of an Acidic Tripeptide in Neurotoxic Dialysate
• The Effect of a Synthetic Thymosin α_1 Fragment on the Inhibition of E-rosette Formation by the Serum of a Patient with Nephrotic Syndrome
• The Effects of Synthetic Glucagon Fragments on Glucose-6-phosphate Dehydrogenase. II
• Synthesis and Effects of Two Peptide Fragments of Thymopoietin II on E-Rosette Forming Cells in the Uremic State
• Synthesis of Bradykinyl-peptide and Peptidyl-bradykinin
• Syntheses of [Phe (4NO_2)^5,Tyr (Me)^8]-and [Tyr (Me)^5,Phe (4NO_2)^8]-Bradykinin

もっと見る 閉じる

スポンサーリンク