The Effect of Thymopoietin II Fragments and Their Analogs on E-Rosette Forming Cells in the Uremic State
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概要
- 論文の詳細を見る
The synthesis of four fragments from dipeptide to pentapeptide, corresponding to amino acids 32 to 36 of thymopoietin II, and four analogs is described, together with their effects on E-rosette forming cells in the uremic state. After incubation with amounts of H-Arg-Lys-Asp-Val-Tyr-OH (residues 32-36) varying from 100 to 200 μg/ml of cell suspension, maximum T-cell rosette formation ranged from 65 to 73% compared with 50 to 52% without the peptide. The activity of H-Arg-Lys-Glu-Val-Tyr-OH was lower than that of H-Arg-Lys-Asp-Val-Tyr-OH. The other fragments and analogs had no effect on the E-rosette formation-inhibiting activity of uremic serum at a dose of 200 μg/ml
- 公益社団法人日本薬学会の論文
- 1980-08-25
著者
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関野 宏
Kidney Research Laboratory Kojinkai
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安孫子 敬
Kidney Research Laboratory Kojinkai
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小野寺 育子
Kidney Center, Sendai Insurance Hospital
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小野寺 育子
Kidney Center Sendai Insurance Hospital
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