Effects of Synthetic Thymopoietin Fragments on Low E-Rosette Forming Cells in a Patient with Lupus Nephritis

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概要

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• Two thymopoietin fragments, H-Val-Thr-Leu-Pro-Ala-Gly-Glu-Gln-Arg-Lys-Asp-Val-Tyr-OH (positions 24-36) and H-Glu-Gln-Arg-Lys-Asp-Val-Tyr-OH (positions 30-36), were synthesized using protecting groups removable by hydrogen fluoride treatment. The in vitro additions of these synthetic fragments could restore the low E-rosette forming capacity of cells in a patient with lupus nephritis to normal levels. The in vitro effects of tridecapeptide (positions 24-36) and heptapeptide (positions 30-36) fragments of thymopoietin on the low E-rosette forming capacity of cells in a patient with lupus nephritis were also compared with that of the synthetic pentapeptide fragment (positions 32-36). The relative potency of the heptapeptide was 65.22 and that of the tridecapeptide was 40.54 based on the pentapeptide (100.00) as a standard.

• 公益社団法人日本薬学会の論文
• 1981-11-25

著者

• 関野 宏

  Kidney Research Laboratory Kojinkai

• 安孫子 敬

  Kidney Research Laboratory Kojinkai

関連論文

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