Synthesis and Immunological Effects of Thymosin α_1 and Its Fragments on Inhibitory Factor in Minimal Change Nephrotic Syndrome
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概要
- 論文の詳細を見る
The octacosapeptide corresponding to the entire amino acid sequence of thymosin α_1 was synthesized using the catalytic hydrogenation procedure at the final deprotection step. The depressed E-rosette forming capacity of lymphocytes caused by a serum factor from a patient in the active stage of MCNS was significantly restored when the lymphocytes were incubated with thymosin α_1. The relative potency of the decapeptide fragment (positions 19-28) was 1.04 and that of the pentadecapeptide fragment (positions 14-28) was 9.83 based on synthetic thymosin α_1 (100.00) as a standard.
- 公益社団法人日本薬学会の論文
- 1980-12-25
著者
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関野 宏
Kidney Research Laboratory Kojinkai
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安孫子 敬
Kidney Research Laboratory Kojinkai
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小野寺 育子
Kidney Center, Sendai Insurance Hospital
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小野寺 育子
Kidney Center Sendai Insurance Hospital
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