Synthesis of a Thymosin β_4-Like Peptide, Deacetyl-thymosin β^<Xen>_4,and Its Restorative Effect on Depressed Lymphocyte Blastogenic Response to Phytohemagglutinin (PHA) in Uremic Patients
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概要
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An analog of thymosin β^<Xen>_4 isolated from ooxytes of Xenopus laevis, deacetyl-thymosin β^<Xen>_4,was synthesized by assembling 6 peptide fragments, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1 : 1) in trifluoroacetic acid in the presence of dimethylselenium. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic tritetracontapeptide was found to have a restoring effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients.
- 公益社団法人日本薬学会の論文
- 1989-09-25
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