Synthesis of the Nonatetracontapeptide Corresponding to the Entire Amino Acid Sequence of Thymopoietin I and Its Effect on the Low E-Rosette-Forming Cells of a Uremic Patient
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概要
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The nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin I was synthesized by successive azide condensation of seven fragments : Boc-(36-41)-NHNH_2,Boc-(30-35)-NHNH_2,Boc-(25-29)-NHNH_2,Boc-(20-24)-NHNH_2,Boc-(16-19)-NHNH_2,Boc-(8-15)-NHNH_2 and Boc-(1-7)-NHNH_2 with H-(42-49)-OBzl. The deprotection of the protected nonatetracontapeptide was achieved by treatment with hydrogen fluoride in the presence of anisole-thioanisole-m-cresol. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a uremic patient with the synthetic nonatetracontapeptide at the dose of 1 μg/ml.
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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