IONOPHORETIC ACTIVITIES OF OLIGOPEPTIDE LACTONES AND RESIN-GLYCOSIDES IN HUMAN ERYTHEROCYTES

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概要

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• Oligopeptide lactones (theonellapeptolides) isolated from the Okinawan marine sponge Theonella swinhoei and resin-glycosides (merremosides) from the tuber of an Indonesian medicinal plant Merremia mammosa were examined regarding their activities in transporting Na^+, K^+, and Ca^<++> ions into human erythrocytes. Each of these lactones, which had been shown, using a supported liquid membrane, to have an ionophoretic effect on the alkali metal ions, transported the ions to a different extent. The ion transporting activities of these compounds were completely lost when the macrocyclic lactone structures were cleaved by sodium methylate. Resin-glycosides with an additional branched glycosyl residue showed much greater ion transporting activities than those without it.

• 公益社団法人日本薬学会の論文
• 1989-06-25

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 明渡 均

  大阪府立成人病センター腫瘍生化学

• 渋谷 博孝

  Faculty of Pharmaceutical Sciences, Osaka University

• 大橋 一慶

  福山大学

• 大橋 一慶

  Faculty of Science, Shizuoka University

• 川西 博之

  大阪大学薬学部

• 川西 博之

  Faculty of Pharmaceutical Sciences, Osaka University

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 新貝 清子

  Research Institute, The Center for Adult Diseases

• 明渡 均

  Research Institute, The Center for Adult Diseases

• 新貝 清子

  Research Institute The Center For Adult Diseases

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