Plasma Protein Binding, Renal Clearance, and Pharmacokinetics of Diuretics in Rabbits
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概要
- 論文の詳細を見る
The transfer of three commercial diuretics (furosemide, bumetanide and hydroflumethiazide) in the biophase was investigated using rabbits. Pharmacokinetic analysis based on the two-compartment open model was performed. The biological half-lives calculated from the β phase of rabbit plasma level time courses were almost the same and were extremely short (20-40 min), in spite of the large differences among the three diuretics in plasma protein binding. The results of renal clearance experiments using rabbits indicated a large contribution of tubular secretion (approximately 80-90%). Therefore, it is suggested that the plasma protein is involved in the transport of diuretics to the kidney.
- 社団法人日本薬学会の論文
- 1980-08-25
著者
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後藤 茂
Faculty Of Pharmaceutical Sciences Kyushu University
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荒木 泰典
Department Of Hospital Pharmacy Okayama University Medical School
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中野 節
Hospital Pharmacy Okayama University Hospital
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後藤 茂
Faculty Of Pharmaceutical Sciences Okayama University
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荒木 泰典
Hospital Pharmacy, Okayama University Hospital
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後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
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