テガフール坐剤の人工膜透過性の比較

概要

論文の詳細を見る
Permeability of artificial membranes to tegaful in suppositories was investigated by using the dissolution apparatus in the paddle method of JP X, Sartorius absorption simulator and a suppository release apparatus. Pemeability was evaluated on the basis of the release of tegaful from suppositories through cellophane and lipid membranes. Five products (A-1, A-2, B-1, B-2 and C) of tegaful suppositories from 3 manufacturers were used. The release of tegaful from product A-2 and B-2 in the method using the dissolution apparatus and the suppository release apparatus was significantly more rapid than that from the remaining products. The release of tegaful from product B-2 with Sartorium absorption simulator was also significantly more rapid than that from product A-1 and C. The similar results were obtained in 3 methods. Therefore, this study suggests that the dissolution apparatus in the paddle method of JP X be applicable for evaluation of the release of tegaful from suppositories.
日本医療薬学会の論文
1985-06-20