アスコルビン酸の輸液中での安定性 (I) : M.V.I., ソービタおよびネオラミン・マルチ混注後の過酸化水素の生成

概要

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Numerous reports have appeared concerning compatibility, photo-degradation and adsorption in infusion solutions. Scince no studies have been done, however, on producing hydrogen peroxide in infusion solutions to which added multi-vitamins, we formulated research to focus on this particular aspect. The production of hydrogen peroxide increased immediately after mixing infusion solutions and multi-vitamins, rising to 11.02 ppm in KN solution 4B combined with M.V.I. and 8.76 ppm or 10.58 ppm in Klinizalz^<[◯!R]> B combined with Sohvita^<[◯!R]> or Neolamin Multi^<[m◯!R ]> respectively. Removal of soluble oxygen and light remarkably affected the on disturbance of the hydrogen peroxide production, while degradation of ascorbic acid (AsA) was observed immediately after mixture initiation.
日本医療薬学会の論文
1994-02-20