EMIT法およびMARKIT法により測定した唾液中抗てんかん剤濃度の比較

概要

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The concentrations of phenytoin, phenobarbital and primidone in plasma and saliva were determined. The result obtained by MARKIT method showed a good agreement with that by EMIT method, with the exception of the determination of low concentration of phenytoin in saliva. However, when the phenytoin concentration in plasma was above 2.0 μ9/ml, it was possible to determine salivary phenytoin in low concentration by adding one of the following operations to EMIT method : 1) concentration determined by CP 1000 and then calculated from the half-dose standard curve of DPH-calibrators diluted by DPH negative human serum ; 2) concentration determined by CP 5000 in similar test method of plasma sample. In both operations, the salivary dilution omitted from EMIT method.
日本医療薬学会の論文
1981-08-20