肝障害ラットの血清GPT値および肝薬物代謝酵素に及ぼすクロルプロマジンの影響

概要

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Effects of chlorpromazine (CPZ) on serum GPT (SGPT) and hepatic microsomal drug-metabolizing enzyme activities in the rat with liver injured by CCI_4 were studied. Rats were intraperitoneally injected with CCI_4 at adose of 0.2 ml/kg every 3 days, and with CPZ at a dose of 5 mg/kg once a day for 48 days. SGPT activity was gradually elevated from the beginning of CCI_4-administration and reached to the maximum after 30 days. The elevation of SGPT value induced by CCI_4-administration was inhibited by the administration of CPZ. In addition, decreases of cytochrome P-450 and cytochrome b_5 by CCI_4-administration were observed. However, CPZ restored the decrease of cytochrome P-450. These results indicate that CPZ protects liver cell damage induced by CCI_4, resulting in that the effect of CPZ on cytochrome P-450 may be important for protecting from drug-induced hepatic injury.
日本医療薬学会の論文