成人生体肝移植患者におけるタクロリムス血中濃度の経時的推移ならびに肝機能検査値との相関性について

概要

論文の詳細を見る
The purpose of this study was to investigate the relationship between blood concentrations of tacrolimus and liver biochemical profiles in living-donor liver transplantation recipients. The results indicated that the tacrolimus blood concentration/dose ratio (C/D ratio) decreased following living-donor liver transplantation. Furthermore, the variation in the C/D ratio and tacrolimus blood concentration was greater at 1 week after surgery than at 2-4 weeks afterwards. We also noted that when the C/D ratio was high total bilirubin was also high, suggesting that a low dosage of tacrolimus is necessary for high-total bilirubin patients. However, there was no definite correlation between AST or ALT and the C/D ratio. It is therefore necessary to control tacrolimus blood concentrations in adult living-donor liver transplantation recipients.
日本医療薬学会の論文
2007-08-10