漢方エキス顆粒製剤中のアセトンおよびメタノール含量の測定

概要

論文の詳細を見る
Determination of acetone and methanol contents in Chinese medicinal extract granules (CMEG) was carried out for their quality test. 14 products combining 4 kinds of CMEG (Hachimijio-gan, Syosaiko-toh, Orengedoku-toh and Kamisyoyou-san) from 4 manufacturers were used in this study. No significant difference was observed in acetone contents of the 14 products, all in the range not more than 10μg/g. However, a considerable difference in methanol contents was observed among manufacturers. Methanol in CMEG prepared by wet-molding showed high content, and in CMEG prepared by dry-molding indicated almost no content. This substance was not detected in 3 products of a manufacturer as a result of a change in granulation method from wet-molding to dry-molding. Only a trace of methanol was found in the decoctions of crude drugs for CMEG. This indicates that the high contents of methanol in CMEG are dependent upon the manufacturing process.
日本医療薬学会の論文
1985-08-20