Preparation and Dissolution Pattern of Eudragit RS Microcapsules Containing Ketoprofen
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概要
- 論文の詳細を見る
Microencapsulation of ketoprofen using Eudragit RS, which is a copolymer synthesized from acrylic and methacrylic acid esters with a low content of quaternary ammonium groups, was investigated. The preparation is based on dispersion of acetone containing the drug in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility in microcapsule preparation was observed. The microcapsules obtained were uniform and free-flowing particles. The dissolution rates of ketoprofen from these microcapsules were considerably decreased as compared with that from ketoprofen powder.
- 公益社団法人日本薬学会の論文
- 1986-06-25
著者
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後藤 茂
Faculty Of Pharmaceutical Sciences Kyushu University
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青山 敏信
Hospital Pharmacy, Faculty of Medicine
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川田 昌和
Faculty Of Pharmaceutical Sciences Kyushyu University
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中村 正宏
Faculty Of Pharmaceutical Sciences Kyushyu University
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後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
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