Effect of the Cholesterol Content on the Stability of Liposomes in the Blood Circulation
スポンサーリンク
概要
- 論文の詳細を見る
Liposomes composed of egg phosphatidylcholine (PC) and cholesterol (Chol), of which ratios (PC/Chol) were 1/1, 1/0.6, 1/0.2 were prepared, and the stabilities of these liposomes in the blood circulation were studied by the double fluorescent labeling method described in the previous report. As the result, it was proved that the liposome composed of 1/1 ratio of PC/Chol was stable enough, but with decreasing Chol contents of liposoomes, entrapped materials were leaked from liposomes. The result obtained in this study was in accordance with the previous reports and double fluorescent labeling method has been found very useful for the study on liposomes.
著者
-
澤原 英幸
Faculty of Pharmaceutical Sciences Kyushu University
-
木下 洋夫
School of Health Sciences, Kyushu University
-
後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
-
後藤 茂
Faculty of Pharmaceutical Sciences, Kyushu University
-
澤原 英幸
Faculty of Pharmaceutical Sciences, Kyushu University
-
木下 洋夫
School of Health Sciences
関連論文
- Transdermal Delivery of Theophylline Using an Ethanol/Panasate 800-Ethylcellulose Gel Preparation
- Relationship between Lipophilicity and Skin Permeability of Various Drugs from an Ethanol/Water/Lauric Acid System
- Effect of Hydrophilic and Lipophilic Vehicles on Skin Permeation of Tegafur, Alclofenac and Ibuprofen with or without Permeation Enhancers
- Evaluation of Enteric Coated Tablet Sensitive to Pancreatic Lipase. II. In Vivo Evaluation
- In Vivo Microdialysis for the Transdermal Absorption of Valproate in Rats
- A NEW STATISTICAL PROCEDURE OF INTERVAL HYPOTHESIS TESTING FOR BIOEQUIVALENCE STUDIES
- In Vivo Microdialysis for Pharmacokinetic Investigations : A Plasma Protein Binding Study of Valproate in Rabbits
- Preparation and Evaluation of Suppositories for RK-28 (a New Radiosensitizer) Using Rabbits
- Pharmacokinetics of RK-28 (a New Radiosensitizer) and Pharmaceutical Design of a Suppository Form Using Rats
- Transport of Aspirin and Its Metabolites through Human Erythrocyte Membrane
- Preparation and Evaluation of Eudragit Gels. V. Rectal Gel Preparations for Sustained Release and Avoidance of First-Pass Metabolism of Lidocaine
- Effect of Sodium Valproate (VPA) on Cerebral Amino Acids : Mechanism of γ-Aminobutyric Acid (GABA) Elevation and Possible Causal Relation of VPA-Induced Encephalopathy and Glutamine Level
- Rate of Gastric Emptying of Phenol Red in a Rabbit
- Effect of Combination of Pharmaceuticals on Gastrointestinal Absorption. III. Combination of Aminopyrine and Barbital. (1)
- Kinetics of Reaction of Dehydroacetic Acid. V. Reaction with Primary Amines. (3)
- Kinetics of Conversion of Diacetylacetone in Aqueous Solution
- Effect of Combination of Pharmaceuticals on Gastrointestinal Absorption. II. Combination of Caffeine with Non-absorbable Drugs
- Effect of Combination of Pharmaceuticals on Gastrointestinal Absorption. I. Combination of Caffeine with a Few Absorbable Drugs
- Optimization of Preparative Conditions for Polylactide (PLA) Microspheres Containing Ovalbumin
- Oral Delivery of Poly (lactide-co-glycolide) Microspheres Containing Ovalbumin as Vaccine Formulation : Particle Size Study
- In Vivo Release of Water-Soluble Drugs from Stabilized Water-in-Oil-in-Water (W/O/W) Type Multiple Emulsions Following Intravenous Administrations Using Rats
- Enhancement Effect of an Ethanol/Panasate 800 Binary Vehicle on Anti-inflammatory Drug Permeation across Excised Hairless Mouse Skin
- Utility of Mixture of Commercially Available Polymers as Constituents of Sustained-Release Microcapsules Containing Cefadroxil or Theophylline
- 水溶性薬物を包含した安定なW/O/W型複合エマルションの調製とその薬物放出性のin Vitro評価
- W/O/W型複合エマルションの内水相中に封入された水溶性薬物の放出性
- Biopharmaceutical Evaluation of Sustained-Release Ethylcellulose Microcapsules Containing Amoxicillin Using Beagle Dogs
- Biopharmaceutical Evaluation of Sustained-Release Ethylcellulose Microcapsules Containing Cefadroxil and Cephradine Using Beagle Dogs
- ペントアンスレン型構造を有する複素環化合物のモノアミン酸化酵素阻害活性(発表論文抄録(1991年))
- ペントアンスレン型構造を有する複素環化合物のモノアミン酸化酵素阻害活性
- ペントアンスレン型複素環化合物の抗不安作用
- Plasma Protein Binding, Renal Clearance, and Pharmacokinetics of Diuretics in Rabbits
- Binding of Diuretics to Human Serum Albumin and to Human Serum from Healthy Adults and Patients with Renal Failure
- Metabolism and Cytotoxieity of Hydrazine in Isolated Rat Hepatocytes(Biological)
- HEPATOTOXICITY OF HYDRAZINE IN ISOLATED RAT HEPATOCYTES
- 放出制御及び生物学的利用能の向上を目指した製剤の開発に関する研究
- 私の薬剤学:マイクロカプセルをいじって20年
- リポソームの血中クリアランスに及ぼす粒子径の影響
- Double Fluorescent Labeling Method Used for a Study on Liposomes
- Structure-Activity Relationship of a New Series of Tricyclic Monoamine Oxidase Inhibitors of Pentanthrene Type
- 塩酸ピレンゼピンのラット消化管における吸収促進(第1報)
- Effect of Humidity Aging on Disintegration, Dissolution and Cumulative Urinary Excretion of Calcium p-Aminosalicylate Formulations(Pharmaceutical)
- Evaluation of Enteric Coated Tablet Sensitive to pancreatic Lipase. I. In Vitro Disintegration Test
- Evaluation of Isonicotinoyl-γ-Aminobutyric Acid (GABA) and Nicotinoyl-GABA as Pro-drugs of GABA
- Effect of Environmental Temperature on the Elimination of Theophylline
- DETECTION OF A NEW SERIES OF MONOAMINE OXIDASE INHIBITORS
- Effect of Modification of Albumin on Tolbutamide-Serum Albumin Binding
- Binding of Sulfonylurea-related Compounds with Bovine Serum Albumin
- Biopharmaceutical Evaluation of Gelatin Microcapsules of Sulfonamides
- Preparation and Evaluation of Gelatin Microcapsules of Sulfonamides
- Effect of the Cholesterol Content on the Stability of Liposomes in the Blood Circulation
- Biopharmaceutical Evaluation of Gelatin Microcapsules of Several Oral Antibiotics
- Preparation and Dissolution Pattern of Eudragit RS Microcapsules Containing Ketoprofen