Evaluation of Isonicotinoyl-γ-Aminobutyric Acid (GABA) and Nicotinoyl-GABA as Pro-drugs of GABA
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概要
- 論文の詳細を見る
Isonicotinoyl-γ-aminobutyric acid (GABA) (IG) and nicotinoyl-GABA (NG), candidate prodrugs of GABA, were assessed by measuring various pharmacological responses such as anticonvulsant effect, prolongation of pentobarbital sleeping time and depressive effect on rearing or ambulation in general behavior, in relation to the GABA level in the mouse brain. The GABA level after the intraperitoneal administration of IG at a dose of 1000 mg/kg increased significantly from 2.30±0.02μmol/g wet wt. in the control to 2.93±0.05μmol/g wet wt., while NG caused only a slight increase in GABA level. IG showed a stronger anticonvulsant effect, greater prolongation of pentobarbital sleeping time and greater depressive effect on rearing in general behavior than NG did. The pharmacological effect of IG or NG corresponded well to the GABA level in the brain.
- 公益社団法人日本薬学会の論文
- 1984-10-25
著者
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後藤 茂
Faculty Of Pharmaceutical Sciences Kyushu University
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松山 賢治
Facutly Of Pharmaceutical Sciences Kyushu University
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松山 賢治
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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野田 敦子
九州大学大学院薬学研究院医療薬科学部門製剤設計学
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野田 敦子
Facutly Of Pharmaceutical Sciences Kyushu University
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五味田 裕
Department of Hospital Pharmacy, Okayama University Medical School
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野田 浩司
産業医科大学附属病院 薬剤
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野田 浩司
Department Of Geology National Science Museum
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五味田 裕
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences
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野田 敦子
Faculty of Pharmaceutical Sciences, Kyushu University
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山下 親正
Faculty Of Pharmaceutical Sciences Kyushu University
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市丸 保幸
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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野田 浩司
産業医大・薬剤部
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市丸 保幸
グラクソスミスクライン(株)cns部
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松山 賢治
Department Of Hospital Pharmacy School Of Medicine Nagasaki University
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野田 浩司
Department Of Hospital Pharmacy School Of Medicine University Of Occupational And Environmental Heal
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五味田 裕
Department Of Hospital Pharmacy Okayama University Medical School
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後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
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