Biopharmaceutical Evaluation of Gelatin Microcapsules of Several Oral Antibiotics
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概要
- 論文の詳細を見る
Microencapsulation of three orally administered antibiotics (ampicillin, amoxicillin and cefalexin) was studied. Good reproducibility in microcapsule preparation was obtained, as in the case of the sulfonamides reported previously. In comparison with the release profile of ampicillin powder, sustained ampicillin release was observed from the microcapsules in the neutral medium. Gastric-emptying-controlled rabbits were used for the in vivo evaluation of microcapsules. No sustained release was observed from microcapsules of amoxicillin and cefalexin. However, the gelatin microcapsules containing ampicillin showed significant sustained release of ampicillin.
- 公益社団法人日本薬学会の論文
- 1983-01-25
著者
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後藤 茂
Faculty Of Pharmaceutical Sciences Kyushu University
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川田 昌和
Faculty of Pharmaceutical Sciences, Kyushu University
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田川 公造
Faculty of Pharmaceutical Sciences, Okayama University
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田川 公造
Faculty Of Pharmaceutical Sciences Okayama University
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川田 昌和
Faculty Of Pharmaceutical Sciences Kyushyu University
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後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
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