Metabolism and Cytotoxieity of Hydrazine in Isolated Rat Hepatocytes(Biological)
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概要
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The relationship between the metabolism and hepatotoxicity of hydrazine(Hz) was studied in an isolated rat hepatocyte system. After incubation at 37℃ for 60 min, the concentration of Hz decreased to 34% of the initial value(from 98 to 33 nmol/ml). A further pronounced loss was observed when Hz was incubated with hepatocytes isolated from rats which had been pretreated with phenobarbital(PB) or rifampicin. Since metyrapone and piperoiiylbutoxide inhibited the metabolism in the systems obtained from both PB-pretreated rats and untreated rats, an important role of hepatic cytochrome P-450 in Hz oxidation was suggested. The difference spectrum of Hz with cytochrome P-450 in isolated rat hepatocytes demonstrated the formation of complexes between metabolic intermediates of Hz and cytochrome P-450. The trypan blue exclusion test, the measurement of K^+ level and the determination of glutathione content retained in the cells were also performed. The results suggested that Hz is cytotoxic to isolated rat hepatocytes.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
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後藤 茂
Faculty Of Pharmaceutical Sciences Kyushu University
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千堂 年昭
Faculty Of Pharmaceutical Sciences Kyushu University
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大野 浩司
Faculty Of Pharmaceutical Sciences Kyushu University
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野田 敦子
九州大学大学院薬学研究院医療薬科学部門製剤設計学
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野田 敦子
Facutly Of Pharmaceutical Sciences Kyushu University
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野田 浩司
産業医科大学附属病院 薬剤
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野田 浩司
Department Of Geology National Science Museum
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野田 敦子
Faculty of Pharmaceutical Sciences, Kyushu University
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野田 浩司
産業医大・薬剤部
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野田 浩司
Department Of Hospital Pharmacy School Of Medicine University Of Occupational And Environmental Heal
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後藤 茂
Faculity of Pharmaceutical Sciences, The University of Tokushima
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後藤 茂
Faculty of Pharmaceutical Sciences, Kyushu University
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