Effect of Drugs on Erythrocytes. I. Influence of pH, Osmotic Pressure and a Few Drugs on Erythrocytes'Destruction

概要

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In order to examine the effect of parenteral solutions on erythrocytes, periodical changes in erythrocyte count were measured by HIAC automatic particle counter and, at the same time, erythrocytes were observed by a scanning electron microscope. It was found that HIAC particle counter is convenient for counting of blood cell number and that changes in the counts of cells in the range of 10-150 μm can be used as an index for the destruction of blood cells. It was also found that removal of ascorbic acid from tetracycline preparations prevented destruction of erythrocytes and that chloramphenicol sodium succinate does not disrupt erythrocytes even in a high concentration. These results indicated that erythrocyte destruction by parenteral solution was possibly due to the pH and osmotic pressure of the drug solution and to additives rather than or in addition to the direct action of drugs. Re-examination of the test methods for hemolysis and establishment of judgement standards are desirable.
公益社団法人日本薬学会の論文
1977-08-25