フェニトイン投与設計における Wargner 法の評価

概要

論文の詳細を見る
Wagner proposed a new and simple method to predict dosage of drugs obeying simple Michaelis-Menten elimination kinetics. The prediction performance of the Wagner's method was evaluated with respect to accuracy and precision on the basis of 148 predictions in 42 outpatients treated with phenytoin (PHT). Mean error (ME), mean absolute error (MAE) and root mean squared error (RMSE) served as a measure of accuracy and precision. The MAE and RMSE were 36.0mg/day, 45.4mg/day, respectively. Therefore, the Wagner's method seemed to be simple and accurate in making routine PHT dosage adjustments.
日本医療薬学会の論文
1987-12-20