フェニトイン投与計画への患者母集団パラメータの応用とその評価

概要

論文の詳細を見る
We investigated the influence and the usefulness of the population pharmacokinetic parameters (PPP) reported by Sheiner et al. [I], Grasera et al. [II],Miller et al. [III],IIIrd committee [IV] and Yukawa et al. [V], on the performance of the Bayesian feedback method in predicting the phenytoin (PHT) dosage. The predictabilities of the Bayesian feedback method using the data of 96 epileptic patients were evaluated. The mean prediction error and mean absolute prediction error were applied for measures of prediction bias and precision. The precision of the initial estimates based on the PPP set [V] and [II] were superior to those baced on other parameters. Using the Bayesian feedback method the prediction values improved from the initial estimates were obtained regardless of the PPP sets used. The Bayesian feedback method seemed to give a prediction relatively insensitive to the population parameters used. We also found no inter-institutional differences in predicting the PHT dosage.
日本医療薬学会の論文
1993-02-20