Estimation of the Molecular Volumes of the Reaction Products between β-Lactam Antibiotics and Aminoglycoside Antibiotics, and Those of the Degradation Products of β-Lactam Antibiotics by Isotachophoresis

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The correlative equations between the molecular volume and the qualitative indication (h_R) for β-lactam antibiotics, the reaction products between β-lactam antibiotics and kanamycin, and the degradation products of β-lactam antibiotics were h_R=0.32+0.080 V^<2/3>_A/|Z|(N=15,r=0.972 for penicillins) and h_R=0.04+0.072 V^<2/3>_A/|Z|(N=12,r=0.987 for cephems). Where V_A is van der Waals volume (Å^3/molecule), h_R is The relative step height in The isotachopherogram, and Z is the electric change, respectively.According to these equations, the molecular volumes of the reaction products between β-lactam antibiotics and the other aminoglycoside antibiotics, and those of the degradation products of β-lactam antibiotics can be estimated from the value of h_R. Also according to the step height in the isotachopherogram, the reaction products or the degradation products may be estimated directly when the electric charge is known.It was confirmed that a molecule of aminoglycoside antibiotics reacted with a molecule of β-lactam antibiotics. Therefore, the inactivation of aminoglycoside antibiotics is much greater than for β-lactam antibiotics when the clinical doses of these antibiotic combinations are used.
社団法人日本薬学会の論文
1990-09-25