輸液中のビタミン K_2 製剤とヘパリン製剤の相互作用

概要

論文の詳細を見る
The compatibility of menatetrenone (VK_2) emulsion stabilized with lecithine in the infusion fluids containing divalent electrolytes and heparin injections was studied. The visual extent of opalescence in the admixtures was inspected, and the hydrodynamic diameter of the lipid droplets in the emulsion was measured using NICOMP photon correlation spectrometer. Samples showing the opalescence or precipitation were subjected to particle counting and sizing. Admixtures of VK_2 emulsion with plasma expanders containing divalent cations showed opalescence or precipitation, but did not containing glucose in place of the divalent cations. The opalescence also occurred in the admixture of VK_2 emulsion with heparin injections in electrolyte solutions containing the divalent cations. These results suggest that the change in the lecithine charge brought on by the divalent cations produces the formation of a bridge of high-molecular compounds such as dextran, gellation and heparin among emulsions.
日本医療薬学会の論文
1995-08-10