Estimation of the Molecular Weight of Ions by Isotachophoresis. IV. : Comparison of the Correlations of Mobility with Molecular Volume and with Molecular Weight

概要

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The determination of the molecular volumes of organic substances for which values of specific gravity (d) are not available was investigated. The values of van der Waals volume (V_A : Å^3/molecule) for aliphatic saturated monocarboxylic acids are closer to those of molecular weight per specific gravity (M/d : cm^3/mol) than those of V_W (cm^3/mol). The slope of the correlative equation between V_A and M/dfor organic anionic substances is 1.03,but that between V_W and M/d is 0.62.The values of V_A for organic anionic substances show a good correlation with the absolute ionic mobility (m_O) as well as M/d. The values of V_A for amino acids and dipeptides also showed a better correlation with m_O than the molecular weight (M). Thus, the values of mobility could be better estimated from the molecular volume than the molecular weight.
社団法人日本薬学会の論文
1988-10-25