滅菌クロルヘキシジン製剤の開封後の安定性および効力

概要

論文の詳細を見る
Sterilized chlorhexidine gluconate solutions (GCH) in 500 ml polypropylene containes are prepared in our hospital pharmacy. To deterrnine the expiration period after unsealing the container, the stability and potency of 0.02% GCH were examined by high-performance liquid chromatography and cultivation tests, respectively. The main ingredient of 0.02% GCH which had been used partially for more than 6 months, was maintained at over 95% of its initial concentration at room temperature. No bacterium nor fungus was evident in the 0.02% GCH partially used at several sections for 2-15 months, when examined by three different cultivation tests. Under the conditions of excess microbe contamination such as falling microbial test and sticking fingers test, 0.02% GCH prevented the growth of microbes. These results suggest that there is only a minor possibility of microbial contamination in the sterilized 0.02% GCH after the container has been unsealed. In general, this preparation may be usable for at least one month after unsealing although the existence of microbes resistant to GCH has been reported.
日本医療薬学会の論文
1996-08-10