Binding of Commercial Diuretics with Bovine Serum Albumin

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概要

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• The binding of seven commercial diuretics with bovine serum albumin (BSA) was investigated at three different temperatures, 5°, 30° and 37°, by the equilibrium dialysis method and at 37° by the dynamic dialysis method. The binding data of diuretics were described on the basis that the sites per BSA molecule can be divided into two classes, except that of hydrochlorothiazide, and each class characterized by the binding constants, K_1,n_1,and K_2,n_2. The thermodynamic values, ⊿G°, ⊿H°, and ⊿S°for the primary site of binding were determined, and were discussed on the basis of the fact that a hydrophobic interaction is formed between diuretics and BSA. It was also shown that there are sizable negative entropy and enthalpy changes in the binding of ethacrynic acid and BSA, and that hydrochlorothiazide is bound very weakly with BSA and has a remarkable diffusion pattern through cellulose membrane in the dynamic dialysis.

• 社団法人日本薬学会の論文
• 1978-08-25

著者

• 中野 節

  Hospital Pharmacy Okayama University Hospital

• 後藤 茂

  Faculty Of Pharmaceutical Sciences Okayama University

• 荒木 泰典

  Hospital Pharmacy, Okayama University Hospital

• 小田原 よき子

  Faculty of Pharmaceutical Sciences, Okayama University

• 小田原 よき子

  Faculty Of Pharmaceutical Sciences Okayama University

関連論文

• Plasma Protein Binding, Renal Clearance, and Pharmacokinetics of Diuretics in Rabbits
• Binding of Diuretics to Human Serum Albumin and to Human Serum from Healthy Adults and Patients with Renal Failure
• Binding of Commercial Diuretics with Bovine Serum Albumin
• 水溶液中における利尿薬の安定性ならびに血清アルブミンとの結合

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