Saponin and Sapogenol. XX. Selective Cleavage of the Glucuronide Linkage in Saponin by Acetic Anhydride and Pyridine Treatment

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概要

• 論文の詳細を見る

• Following the previously described two selective cleavage methods (i.e. photolysis and lead tetraacetate degradation) for the glucuronide linkage in the oligoglycosides, it has been found that acetic anhydride and pyridine treatment is also an effective method to selectively cleave the glucuronide-saponin at the glucuronide moiety. The degradation method has been shown to be different from ordinary acetolysis and by the present method, the glucuronide-saponin, which possesses a free carboxyl function and two carbohydrate residues at C-2'and C-4'in its glucuronide moiety, is decomposed to furnish the acetylated derivatives of the genuine sapogenol and those of the carbohydrate residues. The reaction pathway initiated by mixed anhydride formation and decarboxylative elimination has been presumed.

• 公益社団法人日本薬学会の論文
• 1977-06-25

著者

• 北川 勲

  Faculty of Pharmaceutical Sciences, Osaka University

• 池西 裕二

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 吉川 雅之

  Faculty of Pharmaceutical Sciences, Osaka University

• 北川 勲

  Faculty Of Pharmaceutical Sciences Osaka University

• 任 光植

  Faculty Of Pharmaceutical Sciences Osaka University:(present Address)college Of Pharmacy Busan Natio

• 池西 裕二

  Faculty of Pharmaceutical Sciences, Osaka University

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