Decreased Tumorigenicity In Vivo When Transforming Growth Factor β Treatment Causes Cancer Cell Senescence(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
We have previously reported that transforming growth factor β (TGF-β) triggers two independent senescence programs, 1) replicative senescence dependent upon telomere shortening and 2) premature senescence independent of telomere shortening, in the cell line of A549 human lung adenocarcinoma. In this study, we examined the possibility that cancer cell tumor phenotypes could be suppressed by forced senescence. We used A549 cells treated with TGF-β for a long time (over 50 days), where senescence was induced in a telomere-shortening-dependent or an independent way. Fully senescent A549 cells were elongated, acquired contact inhibition capabilities when reaching confluence, and secreted the senescence-associated cytokine IL-6. Furthermore, senescent A549 cells had no tumorigenicity in nude mice. These results indicate that the forced induction of senescence in cancer cells may be a novel and potentially powerful method for advancing anti-cancer therapy.
- 社団法人日本農芸化学会の論文
- 2003-04-23
著者
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Katakura Y
Fac. Of Agriculture Kyushu Univ.
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KATAKURA Yoshinori
Department of Genetic Resources Technology, Faculty of Agriculture
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TABIRA Yukiko
Graduate School of Bioresources and Bioenvironmental Sciences
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SHIRAHATA Sanetaka
Department of Genetic Resources Technology, Faculty of Agriculture
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TERUYA Kiichiro
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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NAKATA Eriko
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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TABIRA Yukiko
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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MIURA Takumi
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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TSUCHIYA Toshie
Division of Medical Devices, National Institute of Health Sciences
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Miura Takumi
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Teruya Kiichiro
Fac. Of Agriculture Kyushu Univ.
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Shirahata Sanetaka
Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog
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Shirahata S
Fac. Of Agriculture Kyushu Univ.
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Katakura Yoshinori
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Katakura Yoshinori
Dep. Of Genetic Resources Technol. Fac. Of Agriculture Kyushu Univ.
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Tamura Takashi
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Nakata Eriko
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Tsuchiya Toshie
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Tsuchiya Toshie
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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SHIRAHATA Sanetaka
Department of Food and Nutrition, Shokei Junior College
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Shirahata Sanetaka
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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Teruya Kiichiro
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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