THE PRODUCTION OF MUTAGENS IN THE INTESTINE OF MICE FED ON A DIET CONTAINING 15 % SORBIC ACID (I)
スポンサーリンク
概要
- 論文の詳細を見る
When mice were fed on a diet containing 15 % sorbic acid for a period up to 6 months, ether extracts of the intestinal contents of the mice were not mutagenic with Salmonella typhimurium TA 98, but the acidic components, obtained by fractionating the ether extracts, showed slightly mutagenic activity with S. typhimurium TA 98, and they required the addition of liver 9,000 xg supernatant fraction for mutagenic activation. These results suggested that mutagens were gradually produced in the intestine and moved into the liver where they were metabolically activated. It is possible to presume that liver carcinoma might be attributable to the production of these mutagens.
- 日本トキシコロジー学会の論文
- 1983-02-25
著者
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TSUCHIYA Toshie
Division of Medical Devices, National Institute of Health Sciences
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Yamaha Tsutomu
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Tsuchiya Toshie
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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