Construction of a Regulatable Cancer-Specific Adenoviral Expression System Using Human Telomerase Reverse Transcriptase Gene Promoter
スポンサーリンク
概要
- 論文の詳細を見る
We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse tetracycline transactivator regulated by the human telomerase reverse transcriptase (hTERT) gene promoter, the other expressing the target gene regulated by the tetracycline response element (TRE). rtTA transactivates target gene expression in the presence of doxycycline. Using these vectors, we constructed an adenoviral expression system, the Tel-On system, which enables highly efficient target gene transduction. This system enabled efficient and regulatable cancer-specific gene expression, and can be used in targeted cancer gene therapy.
- 社団法人 日本農芸化学会の論文
- 2008-06-23
著者
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Katakura Y
Fac. Of Agriculture Kyushu Univ.
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KATAKURA Yoshinori
Department of Genetic Resources Technology, Faculty of Agriculture
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UDONO Miyako
Graduate School of Bioresources and Bioenvironmental Sciences
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KATSUKI Kazuyuki
Graduate School of Systems Life Sciences, Kyushu University
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YAMASHITA Makiko
Department of Genetic Resources Technology, Faculty of Agriculture
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FUJIKI Tsukasa
Department of Genetic Resources Technology, Faculty of Agriculture
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SHIRAHATA Sanetaka
Department of Genetic Resources Technology, Faculty of Agriculture
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Shirahata Sanetaka
Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog
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Shirahata S
Fac. Of Agriculture Kyushu Univ.
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Yamashita Makiko
Fac. Of Agriculture Kyushu Univ.
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Katakura Yoshinori
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Katakura Yoshinori
Dep. Of Genetic Resources Technol. Fac. Of Agriculture Kyushu Univ.
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Maeyama Yoshiaki
R & D Division Nippon Luna Inc.
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Fujiki Tsukasa
Faculty Of Agriculture Kyushu University
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YOSHIZAKI Kaichi
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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UDONO Miyako
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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KATSUKI Kazuyuki
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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FUNATA Masaaki
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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IMADA Yusuke
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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Funata Masaaki
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Imada Yusuke
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Yoshizaki Kaichi
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Yamashita Makiko
R & D Division Nippon Luna Inc.
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Katsuki Kazuyuki
Graduate School Of Systems Life Sciences Kyushu University
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SHIRAHATA Sanetaka
Department of Food and Nutrition, Shokei Junior College
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Shirahata Sanetaka
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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