Pro-Senescent Effect of Hydrogen Peroxide on Cancer Cells and Its Possible Application to Tumor Suppression
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概要
- 論文の詳細を見る
Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We investigated to determine whether mild oxidative stress would trigger SIPS in a human tumor cell line, human lung adenocarcinoma A549. The results showed that sublethal concentrations of H2O2 induced SIPS in A549 cells and consequently attenuated, but did not completely eliminate, the tumorigenicity of these cells. We next investigated the reasons for this incomplete impairment of tumorigenicity in A549 cells in SIPS. The results suggested that H2O2-treated A549 cells are composed of a heterogeneous cell population: one is sensitive to H2O2, and the other is resistant or undergoes reversal; the latter reverted to their original tumorigenic form. The molecular mechanisms determining the cellular fate of tumor cells in SIPS should be identified in order to make use of SIPS and oncogene-induced senescence in tumor cells as methods of tumor suppression.
- 社団法人 日本農芸化学会の論文
- 2009-02-23
著者
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Katakura Y
Fac. Of Agriculture Kyushu Univ.
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KATAKURA Yoshinori
Department of Genetic Resources Technology, Faculty of Agriculture
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UDONO Miyako
Graduate School of Bioresources and Bioenvironmental Sciences
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YAMASHITA Makiko
Department of Genetic Resources Technology, Faculty of Agriculture
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FUJIKI Tsukasa
Department of Genetic Resources Technology, Faculty of Agriculture
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SHIRAHATA Sanetaka
Department of Genetic Resources Technology, Faculty of Agriculture
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Shirahata Sanetaka
Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog
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Shirahata S
Fac. Of Agriculture Kyushu Univ.
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Yamashita Makiko
Fac. Of Agriculture Kyushu Univ.
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Katakura Yoshinori
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Tsuchiya T
Tsukuba Safety Assessment Laboratories Banyu Pharmaceutical Co. Ltd.
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Katakura Yoshinori
Dep. Of Genetic Resources Technol. Fac. Of Agriculture Kyushu Univ.
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Tamura Takashi
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Maeyama Yoshiaki
R & D Division Nippon Luna Inc.
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Fujiki Tsukasa
Faculty Of Agriculture Kyushu University
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YOSHIZAKI Kaichi
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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TSUNEMATSU Takahiro
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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UDONO Miyako
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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Tsuchiya Toshie
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Yoshizaki Kaichi
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Yamashita Makiko
R & D Division Nippon Luna Inc.
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SHIRAHATA Sanetaka
Department of Food and Nutrition, Shokei Junior College
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Shirahata Sanetaka
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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