Dietary Fructooligosaccharides Induce Immunoregulation of Intestinal IgA Secretion by Murine Peyer's Patch Cells(Food & Nutrition Science)
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概要
- 論文の詳細を見る
Probiotic supplements induce immunological responses in the host, and dietary fructooligosaccharides (FOS) stimulate the growth of selected intestinal microflora. In this study we investigated the immunological influences of orally administrated FOS. BALB/c mice were oral administered 0-7.5% FOS for 6 weeks, and the intestinal mucosal immune responses were measured. In the 2.5%-FOS group, fecal IgA was significantly increased. IgA secretion by Peyer's patch (PP) cells was upregulated in a dose-dependent way in response to FOS and CD4^+ T cells from PP showed a dose-dependent increase in production of interferon-γ and interleukin (IL) 10, and a high response in production of IL-5 and IL-6. In contrast, FOS suppressed serum IgG1. Our findings suggest that FOS supplementation changes the intestinal environment of microflora, and leads to upregulation of IgA secretion in CD4^+ PP cells in intestinal mucosa, and to suppression of the systemic immune response to type 2 helper T (Th2) dominant.
- 社団法人日本農芸化学会の論文
- 2003-04-23
著者
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Nakamura Ryo
Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University
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Kato Rina
Department Of Anesthesiology And Medical Crisis Management Nagoya City University Graduate School Of
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Hosono Akira
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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Hosono Akira
Department Of Biochemistry Osaka Medical College
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Kimura Teiji
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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OZAWA Akane
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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OHNISHI Yoshie
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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NAKANISHI Yusuke
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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Ozawa Akane
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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Ohnishi Yoshie
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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Nakamura Ryo
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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Nakamura Ryo
Department Of Applied Biological Sciences School Of Agricultural Science Nagoya University
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Nakanishi Yusuke
Department Of Food Science And Technology College Of Bioresource Sciences Nihon University
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Hosono Akira
Department of Applied Biological Chemistry, The University of Tokyo
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